The formation of mature large rRNAs from larger primary transcripts is very different in bacterial and mammalian cells. In both, cotranscription can help to assure the coordinated production of various rRNA species. However, in bacteria, processing is ordered, initiated by cleavages at double‐stranded stems which enclose the mature sequences; several cleavages are required to produce each mature terminus; and the final steps occur in polysomes, apparently linked to continued protein synthesis. In mouse cells, in contrast, cleavages generate nearly all mature (...) termini stochastically and directly, with no evidence for double‐stranded stems as cleavage signals; and processing occurs in the nucleolus, long before any new rRNA chains arrive in polysomes. Spacer sequences also serve different potnetial functions at the evolutionary extremes. In bacteria, transcribed spacer sequences are associated with different secondary structures in the pre‐rRNA compared to the mature rRNA, and these may promote ribosome formation. In mammalian cells, analyses are too premature to assign any comparable function to transcribed spacer sequences, but the non‐transcribed spacers are probably critical in the organization and replication of nucleoli, functions that are absent from bacteria. (shrink)

During the second half of the XX century drug addiction ceased to be only the epiphenomenon of crime, prostitution and a number of other social-relations deviation, and became a constant value of post-industrial society and at the end of XX century turned into a global problem of mankind. A new form of mass neurosis shows that drug dependence is nowadays socially conditioned mental degeneration, caused by activation of unconscious collective archetypes that are experienced depending on the corresponding situation. The identification (...) of the sacred plant soma/haoma with the marihuana enables us to not only to make clear the light and the dark sides of this archetype, but also to figure out that the reduction of the drug addiction problem, to the acceptable for the society level, is possible only if a man will be able to satisfy his “life-asserting, vital needs”, if he will be able to regain the true meaning of life. (shrink)

R.I.G Hughes offers the first detailed and accessible analysis of the Hilbert-space models used in quantum theory and explains why they are so successful.

Group size is a function of relative neocortical volume in nonhuman primates. Extrapolation from this regression equation yields a predicted group size for modern humans very similar to that of certain hunter-gatherer and traditional horticulturalist societies. Groups of similar size are also found in other large-scale forms of contemporary and historical society. Among primates, the cohesion of groups is maintained by social grooming; the time devoted to social grooming is linearly related to group size among the Old World monkeys and (...) apes. To maintain the stability of the large groups characteristic of humans by grooming alone would place intolerable demands on time budgets. It is suggested that (1) the evolution of large groups in the human lineage depended on the development of a more efficient method for time-sharing the processes of social bonding and that (2) language uniquely fulfills this requirement. Data on the size of conversational and other small interacting groups of humans are in line with the predictions for the relative efficiency of conversation compared to grooming as a bonding process. Analysis of a sample of human conversations shows that about 60% of time is spent gossiping about relationships and personal experiences. It is suggested that language evolved to allow individuals to learn about the behavioural characteristics of other group members more rapidly than is possible by direct observation alone. (shrink)

R.I.G. Hughes presents a series of eight philosophical essays on the theoretical practices of physics. The first two essays examine these practices as they appear in physicists' treatises (e.g. Newton's Principia and Opticks ) and journal articles (by Einstein, Bohm and Pines, Aharonov and Bohm). By treating these publications as texts, Hughes casts the philosopher of science in the role of critic. This premise guides the following 6 essays which deal with various concerns of philosophy of physics such as laws, (...) disunities, models and representation, computer simulation, explanation, and the discourse of physics. (shrink)

R.I.G. Hughes presents a series of eight philosophical essays on the theoretical practices of physics. The first two essays examine these practices as they appear in physicists' treatises and journal articles. By treating these publications as texts, Hughes casts the philosopher of science in the role of critic. This premise guides the following six essays which deal with various concerns of philosophy and physics such as laws, disunities, models and representation, computer simulation, explanation, and the discourse of physics.

The urgency of the research topic is that the attempt, through the prism of higher education in Ukraine, is to outline the factors and opportunities for forming a positive image of a modern teacher as the basis for the competitiveness of a higher educational institution. The purpose of the article is: rethinking the teacher’s image in conditions of growing demands and increasing competitiveness among higher education institutions. The objectives of the study are to summarize the data of the investigated problem (...) and to develop a model for the development of theoretical aspects of forming a teacher’s positive image in the context of the growth of the status of the university, and an analysis of the interdependence of the teacher’s image and his professional competence, practical skills, and the ability to associate theory with practice. The research methodology is general scientific and special-disciplinary methods of scientific research. In particular, the methods of theoretical generalization, analogy and abstraction are used to clarify the conditions, specifics and realities of the modern educational process, in particular – in higher educational institutions; deduction and induction, analysis and synthesis – to identify systemic problems of Ukrainian universities the needs satisfaction of educational services users; the synthesis of progressive ideas on designing ways to enhance the teacher’s positive image in the context of the growth of the status of higher education institutions. Also, special-disciplinary methods of scientific research are used: comparison, systematization and grouping – to generalize the model of development of theoretical aspects of creating of a positive image of the teacher in the context of the formation of the image of the university; analytical – in the analysis of the interdependence of the teacher's image and his professional competence, practical skills and ability to associate theory with practice, etc. The result of the study is a theoretical understanding of the teacher’s image in the context of the formation of the competitiveness of a higher educational institution. The result of the analysis is the constant, systematic improvement of their own professional competencies. And only under this condition, the teacher will be able to rely on the authority and respect among students and colleagues. It is noted that the current state of higher education dictates the necessity of finding new ways of solving problems of increasing the efficiency of not only training, preparation of a specialist in the labor market, but also the efficiency of the activity of a higher educational establishment in conditions of autonomy. Conclusion. The positive image of the teacher, and in general the educational institution, will increase the authority of the professions and specialties of higher education. And philosophy itself should assume responsibility for the formation of the future teacher, since since ancient times, philosophy has been, is and will be the reason for the comprehension of wisdom. The image of a modern teacher largely depends on his professional competence in practical skills and the ability to instruct students to study the theory in close relationship with practice. After all, knowledge becomes effective only in the applied aspect, in particular, when applying the principle of “theory-practice-theory". (shrink)

I shall argue here that the reason supererogatory acts are not obligatory is that they require too much personal sacrifice, and that in order for an act to be supererogatory, it must have a kind of result that you would have an obligation to bring about if you could do so with no personal sacrifice. I further argue that traditional utilitarianism should be modified so as not to treat supererogatory acts as obligatory.

Act Utilitarianism has traditionally been regarded as the view that you should always perform the action that will bring about the greatest possible excess of happiness over unhappiness or, if there is no such alternative, the least possible excess of unhappiness over happiness.1 Following Rawls, I shall call this the classical principle. An alternative which Rawls calls the average principle is the view that you should always do the thing that will bring about the highest possible average happiness level. Rawls, (...) Rescher and Broad2 regard the average principle as superior to the classical principle, and there are considerable grounds for supposing that Mill accepted the average principle.3 Smart favours the classical position but confesses that if someone doesn't feel the same way, he doesn't know how to argue with him.4. (shrink)

Science and religion have been described as the “two dominant forces in our culture”. As such, the relation between them has been a matter of intense debate, having profound implications for deeper understanding of our place in the universe. One position naturally associated with scientists of a materialistic outlook is that science and religion are contradictory, incompatible worldviews; however, a great deal of recent literature criticises this “conflict thesis” as simple-minded, essentially ignorant of the nature of religion and its philosophical (...) and theological underpinnings. In this first part of a two-part article, I set out the wide-ranging background required for a proper understanding of the debate as a preliminary for the second part, in which Ian Barbour ’s influential four-fold typology of science-religion relations is critically assessed, leading to the conclusion that the conflict model is not to be so easily dismissed. (shrink)

Relevance of research. Any religion in the world emphasizes the woman's femininity, namely an anthropological feature that does not require similarity with the functional features of her husband. However, in turn, it has the potential of a comprehensive development of the individual as a mother, and the realization of the role of women in society. The misconceptions that maternity lifts women's potential and suppresses their personal development causes a lot of controversial issues that lead to negative manifestations of gender inequality. (...) Negative manifestations of the perception of false positions lead to terrible structural changes in society, ruin the foundations of the laws of motherhood, have consequences of the aging of the nation, the loss of human spiritual humanism. Women lose the opportunity to feel like a mother and transfer their love of work to work as a child. Therefore, its main base anthropological identity is reduced to zero in this case and makes a woman "uncertain" gender, which will never find its place in society. The aim of the study.It based on the study of the anthropological horizons of gender inequality within the framework of religious canons and modern trends in the manifestation of business, the loss of anthropological value of women. The author's team has proved that each of the religions of the world pays much attention to women as mothers, their roles in society with exceptional abilities and special qualities. None of the religions does restrict women in revealing these abilities, but places anthropological peculiarity on the first place of a woman-mother, guardian of the family. Religion acts as a universal anthropological phenomenon, which reveals each individual essential element characteristic of every person and emphasizes its importance for society. (shrink)

The Oxford text of this passage reads as follows:This gives the received text and punctuation. No generally agreed meaning has been found in the opening sentence as it thus stands; nor have any of the numerous alternative versions which have been proposed gained widespread support. In this paper I suggest that good sense can, after all, be made of this passage in its received form.

In 1962 appeared one of the classic articles in Anglo-Saxon manuscript studies, the publication of two eleventh-century fragments of leaves of Old English found in the binding of a seventeenth-century printed book in the library of the University of Kansas, Lawrence. The fragment that more nearly concerns the present article now carries the shelf mark Pryce MS C2:1 in the Kenneth Spencer Research Library . It is a large part of a single leaf from The Legend of the Holy Cross (...) before Christ, an edifying work known in full only in a twelfth-century copy, Oxford, Bodleian Library, MS Bodley 343, fols. 14v–20v . Working from a photograph the great paleographer and codicologist N. R. Ker attributed the hand of the Kansas fragment to the scribe who also wrote the texts of two bits of the same work found in the library of Matthew Parker, archbishop of Canterbury , at Corpus Christi College, Cambridge, now MS 557 . He concluded, no doubt rightly, that all three are part of one manuscript. (shrink)

It is shown that a formula of modal propositional logic has precisely the same models as a sentence of the first-order language of a single dyadic predicate iff its class of models is closed under ultraproducts. as a corollary, any modal formula definable by a set of first-order conditions is always definable by a single such condition. these results are then used to show that the formula (lmp 'validates' mlp) is not first-order definable.

Data from various settings suggest that there is an upper limit of about four on the number of individuals who can interact in spontaneous conversation. This limit appears to be a consequence of the mechanisms of speech production and detection. There appear to be no differences between men and women in this respect, other than those introduced by women’s lighter voices.

I try to show that there is much sap (synthetic a priori) knowledge although one may not find many, or even any, sap true statements in most natural languages. Reasons are given for the difficulty of expressing sap truths in natural languages, but it is argued that these are not necessary features of language as such. There are, then, sap true statements in some possible languages.Admission of the sap gives one a way of distinguishing logical from metaphysical possiblity. Something is (...) metaphysically impossible just in case it is a sap truth that it is impossible. I argue that the realm of logically possible entities is vastly larger than the realm of metaphysically possible entities.My.defence of the sap begins with a partial defence of the analytic/synthetic distinction. In particular, I attack the intentionality circle argument,Quine's indeterminacy thesis and some applications of the Kripke/Putnam theory of meaning for natural kind terms. Without being a conclusive defence of the analytic/synthetic distinction, this section makes the defence of the sap more secure. Arguments are then mounted in direct defence of the sap by showing that the purported reduction of sap truths to analytic truths is mistaken. Examples are adduced to show that, even where expressions of natural language fail, one can stipulate usage in ways that allow expression of sap truths. I then consider and reply to various objections, giving an example of the sort of meaning theory which illegitimately legislates the analyticity of any purported sap true statement. (shrink)

The present stage of development of the philosophy of language is marked by the joining of efforts of philosophers, logicians, and linguists for solution of one of the most difficult problems posed by the progress of scientific knowledge - the problem of modeling the aspect of meaning, of semantics, of natural language. The solution of this problem governs not only the building of a general theory of language, not only scientific explanation of the phenomenon of the understanding of language and (...) solution of numerous problems of practical importance with respect to automatic language processing, but also the defining of the place and function of language in the process of cognition and understanding of the world, a matter that is fundamental to methodology. (shrink)

Data on the number of adults that an individual contacts at least once a month in a set of British populations yield estimates of network sizes that correspond closely to those of the typical “sympathy group” size in humans. Men and women do not differ in their total network size, but women have more females and more kin in their networks than men do. Kin account for a significantly higher proportion of network members than would be expected by chance. The (...) number of kin in the network increases in proportion to the size of the family; as a result, people from large families have proportionately fewer non-kin in their networks, suggesting that there is either a time constraint or a cognitive constraint on network size. A small inner clique of the network functions as a support group from whom an individual is particularly likely to seek advice or assistance in time of need. Kin do not account for a significantly higher proportion of the support clique than they do for the wider network of regular social contacts for either men or women, but each sex exhibits a strong preference for members of their own sex. (shrink)

There has been a revival of interest in Hegel of late among English-speaking philosophers. Although he is still regarded as maddeningly obscure, a number of important philosophers have been attracted by a doctrine prominently associated with Hegel, the coherence theory of truth. In order to hold the coherence theory of truth, it is obvious that you must hold what might be called the coherence theory of truth-testing as well: for if this theory is wrong and we can test some statements (...) by, for example, introspection as well as in terms of coherence, truth must involve something more than just coherence. My arguments against the coherence theory of truth-testing, since it is implied by the coherence theory proper, are indirectly against the coherence theory as well. I also argue that unless some version of the Private Language Argument is successful, it is virtually impossible to defend the coherence theory of truth-testing without denying the existence of experiences, thereby committing oneself to materialism. (shrink)

There has been a revival of interest in Hegel of late among English-speaking philosophers. Although he is still regarded as maddeningly obscure, a number of important philosophers have been attracted by a doctrine prominently associated with Hegel, the coherence theory of truth. In order to hold the coherence theory of truth, it is obvious that you must hold what might be called the coherence theory of truth-testing as well: for if this theory is wrong and we can test some statements (...) by, for example, introspection as well as in terms of coherence, truth must involve something more than just coherence. My arguments against the coherence theory of truth-testing, since it is implied by the coherence theory proper, are indirectly against the coherence theory as well. I also argue that unless some version of the Private Language Argument is successful, it is virtually impossible to defend the coherence theory of truth-testing without denying the existence of experiences, thereby committing oneself to materialism. (shrink)

There can be no doubt that we do know one another. We know that others exist and we know a good deal about others. The question is how we know others. To say that others do not exist would be to assert a solipsism—a theory which no serious philosopher has ever maintained. Solipsism is absurd. Not because it is self-contradictory, for there is nothing self-contradictory in the notion that I alone exist having the experiences and thoughts which I do have (...) and that apart from me nothing and no one else exists. It is absurd simply because others do exist and I know this; because, that is to say, it contradicts the known evidence. This is the sole—but the adequate—ground for concluding solipsism to be absurd. Any discussion of this present problem, therefore, must begin with, the recognition of the fact that knowledge of others occurs. (shrink)

John Searle attempts to show through a consideration of promising that at least some ‘ought’ statements can be derived from ‘is’ statements. He thinks that you can determine on purely factual grounds that a person has made a promise, and that it follows logically from the statement that a person has made a promise that he has at least a prima facie obligation to do the thing he promised to do. I agree with but not with.